Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Powdered solution technology involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. A liquid layer is formed on the particle surface which is instantly adsorbed by the coating material. This leads to the formation of a dry, free flowing and compressible powder. Coating material is required to cover the surface and maintain the powder flowability. A powder of known quantity can only retain limited amount of liquid medication while maintaining acceptable flowability and compressibility. A mathematical model has been introduced for liquisolid system that desires to have an acceptable flowable and compressible properties. Two fundamental properties characterize this model. They are the flowable liquid retention potential and the compressible liquid retention potential.
| Published in | Science Frontiers (Volume 4, Issue 2) |
| DOI | 10.11648/j.sf.20230402.11 |
| Page(s) | 17-24 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Liquisolid Technique, Solubility, Bioavailability, Non-Volatile Solvents, Drug Release
| [1] | Naseem A, Olliff C J, Martini LG, Lloyd AW, Effects of plasma irradiation on the wettability and dissolution of compacts of griseofulvin Int. J. Pharm., 2004; 269, 443-450. |
| [2] | Wong SM, Kellaway IW, Murdan S, Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles Int. J. Pharm., 2006; 317, 61–68. |
| [3] | Saleki-Gerhardt A, Ahlneck C, Zografi G, Assessment of disorder in crystalline solids, Int. J. Pharm., 1994; 101, 144. |
| [4] | Iskandarsyah, Fudholi A, Riswaka, S. The effect of two cellulose derivatives as solid dispersion carriers on physical properties and dissolution rate of dexamethasone tablets. Maj Farm Indones 1999; 10 (1): 1-8. |
| [5] | Sugimoto M, Okagaki T, Narisawa S, Koida Y, Nakajima K. Improvement of dissolution characteristics and bioavailability of poorly water-soluble drugs by novel co- grinding method using water-soluble polymer. Int J Pharm. 1998; 160: 11–19. |
| [6] | Edward Lay, Wilmington E. Handbook of modern pharmaceutical science in separation science and technology. 2021; 173-233. |
| [7] | Javadzadeh Y, Siahi-Shadbad, M. R, Barzegar-Jalali M, Nokhodchi A. Enhancement of dissolution rate of piroxicam using liquisolid compacts. Farmaco 2005, 60: 361-365. |
| [8] | Javadzadeh Y, Siahi M. R, Asnaashari S, Nokhodchi A. An investigation of physicochemical properties of piroxicam liquisolid compacts. Pharmaceutical Development & Technology 2007, 12: 337-343. |
| [9] | Johannes KF. Dispersions, emulsions and foams. Petroleum Engineer’s guide to oil field chemicals and fluids. 2012; 165-174. |
| [10] | Chueluecha Nut, Kaewchada Amarapom, Jaree Attasak. Enhancement of biodiesel synthesis using co-solvent in a packed-microchannel. Journal of industrial and engineering chemistry 2017; 51: 162-171. |
| [11] | Badadha S, Dalavi N. Review on self nano-emulsifying drug delivery system. Sys Rev. Pharm. 2022; 13: 63-68. |
| [12] | Betageri GV. Self-emulsifying drug delivery systems and their marketed products. A review. Asian J. Pharm. 2019; 13: 73-84. |
| [13] | Cherniakov I, Domb AJ, Hoffman A. Self nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects. Expert Opin Drug Deliv. 2015; 12 (7): 1121-33. |
| [14] | Javadzadeh Y, Musaalrezaei L, Nokhodchi A. Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices. Int J Pharm 2008; 362: 102–108. |
| [15] | Nokhodchi A, Aliakbar R, Desai S. Liquisolid compacts: the effect of cosolvent and HPMC on theophylline release. Colloids Surf B Biointerfaces 2010; 79: 262–269. |
| [16] | Pavani E, Noman S, Syed IA. Liquisolid technique based sustained release tablet of trimetazidine dihydrochloride. Drug Invention Today 2013; 5: 302–310. |
| [17] | Charman SA, Charman WN. Oral modified release delivery systems. In: Rathbone MJ, Hadgraftb J, Roberts MS, editors. Modified release drug delivery technology. NewYork: 20p. 1–9. |
| [18] | Saeedi M, Akbari J, Morteza-Semnani K. Enhancement of dissolution rate of indomethacin using liquisolid compacts. Iran J Pharm Res 2011; 10: 25–34. |
| [19] | Karmarkar AB, Gonjari ID, Hosmani AH. Dissolution rate enhancement of fenofibrate using liquisolid tablet technique. Lat Am J Pharm 2009; 28: 219–225. |
| [20] | Hentzschel CM, Sakmann A, Leopold CS. Suitability of various excipients as carrier and coating materials for liquisolid compacts. Drug Dev Ind Pharm 2011; 37: 1200–1207. |
| [21] | Nokhodchi A, Hentzschel CM, Leopold CS. Drug release from liquisolid systems: speed it up, slow it down. Expert Opin Drug Deliv 2011; 8: 191–205. |
| [22] | Fuji Chemical Industry Co., Ltd. 20Fujicalin® – The unique DCPA. Available from: http://www.fujicalin.com/product/general_properties.php. [Accessed 28 March 2016]. |
| [23] | Fuji Chemical Industry Co., Ltd. 20Neusilin ® – The specialty excipient. Available from: http://www.neusilin.com/product/general_properties.php. [Accessed 28 March 2016]. |
| [24] | Vranikova B, Gajdziok J, Vetchy D. Determination of flowable liquid retention potential of aluminometasilicate carrier for liquisolid systems preparation. Pharm Dev Technol 2015; 20: 839–844. |
| [25] | Spireas S, Bolton SM. Liquisolid systems and methods of preparing same. US5968550, 1999. |
| [26] | Spireas S. Liquisolid system and method of preparing same. U. S Patent 6423339B1, 2002. |
| [27] | Spireas SS, Jarowski CI, Rohera BD. Powdered solution technology: principles and mechanism. Pharm Res 1992; 9: 1351–1358. |
| [28] | Kadam SV, Shinar DM, Saudagar RB. Review on solubility enhancement techniques. Int J Pharm Biol Sci 2013; 3: 462-75. |
| [29] | Srujan Kumar M, Balaji A, Kanakaiah K, Mahalakshmi K. Liquisolid compacts: a novel approach for the enhancement of solubility of poorly soluble drugs. Indo Am J Pharm Res 2013; 3: 4386-95. |
| [30] | Pezzini BR, Beringhs AO, Ferraz HG. Liquisolid technology applied to pellets: evaluation of the feasibility and dissolution performance using felodipine as a model drug. Chem Eng Res Des 2016; doi: 10.1016/ |
| [31] | Shashidher B, Madhusudhanrao Y, Venkateswarlu V. The liquisolid technique: an overview. Braz J Pharm Sci 2011; 47: 475-82. |
| [32] | Kulkarni AS, Nagesh HA, Madhav SM, Jayashree BG. Liquisolid system: a review. Int J Pharm Sci Nanotechnol 2010; 3: 795-802. |
| [33] | Manpreet K, Rajni B, Sandeep A. Liquisolid technology: a review. Int J Adv Pharm Sci 2013; 4: 1-5. |
| [34] | Doijad RC, Pathan AB, Gaikwad SS, Baraskar SS, Pawar NB, Maske VD. Liquisolid: a novel technique for dissolution enhancement of poorly soluble drugs. Int J Curr Pharm Res 2012; 3: 735-49. |
| [35] | Vijaykumar N, Sridhar T, Anilkumar C, Pragathi K. Enhancement of oral bioavilability of naproxen by liquisolid compaction technology: in vitro, in vivo evaluation. Indo Am J Pharm Res 2013; 3: 1359-69. |
| [36] | Bhumi BP, Chainesh NS. Recent research on liquisolid technology for solubility enhancement-a review. Int J Adv Pharm 2016; 5: 1-7. |
| [37] | Harshil MP, Chainesh NS. A review-recent research on liquisolid compact for solubility and dissolution enhancement. J Pharm Sci Biosci Res 2016; 6: 628-34. |
| [38] | Khames A. Liquisolid technique: a promising alternative to conventional coating for improve ment of drug photostability in solid dosage forms. Drug Deliv 2013; 10: 1335–1343. |
| [39] | Sandip V, Vishal S, Nilesh G, Bakde BV. Effect of dissolution rate by liquisolid compact approach: an overview. Int J Chem Pharm Sci 2012; 1: 1013-8. |
| [40] | Vijaykumar N, Ramarao T, Jayaveera KN. Liquisolid compacts: a novel approach to enhance bioavailability of poorly soluble drugs. Int J Pharm Biol Sci 2011; 1: 89-102. |
| [41] | Ganesh NS, Deecaraman, Vijayalakshmi KNS, Raju L, Ramesh B. Formulation and evaluation of sustained release lornoxicam by liquisolid technique. Int J Pharm Sci Rev Res 2011; 11: 53-7. |
| [42] | Surti N, Patel DS, Pipaliya RM. Liquisolid tablets for dissolution enhancement of a hypolipidemic drug. Indian J Pharm Sci 2015; 77: 290-8. |
| [43] | Meena K, Sneha M. A review on pioneering technique-liquisolid compact and applications. Res J Pharm Biol Chem Sci 2015; 6: 220-7. |
| [44] | liquisolid tablet technique. Eur J Pharm Biopharm 2008; 69: 342–347. |
| [45] | Gubbi SR, Jarag R. Formulation and characterization of atorvastatin calcium liquisolid compacts. Asian J Pharm Sci 2010; 5: 50–60. |
| [46] | Karmarkar AB, Gonjari ID, Hosmani AH. Evaluation of in vitro dissolution profile comparison methods of sustained release tramadol hydrochloride liquisolid compact formulations with marketed sustained release tablets. Drug Discov Ther 2010; 4: 26–32. |
| [47] | Singh SK, Srinivasan KK, Gowthamarajan K. Influence of formulation parameters on dissolution rate enhancement of glyburide using liquisolid technique. Drug Dev Ind Pharm 2012; 38: 961–970. |
| [48] | Javadzadeh Y, Jafari-Navimipour B, Nokhodchi A. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine). Int J Pharm 2007; 341: 26–34. |
| [49] | Spireas S, Sadu S. Enhancement of prednisolone dissolution properties using liquisolid compacts. Int J Pharm 1998; 166: 177–188. |
| [50] | Fahmy RH, Kassem MA. Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur J Pharm Biopharm 2008; 69: 993–1003. |
| [51] | Komala DR, Janga KY, Jukanti R. Competence of raloxifene hydrochloride loaded liquisolid compacts for improved dissolution and intestinal permeation. J Drug Deliv Sci Technol 2015; 30: 232–241. |
| [52] | Sanka K, Poienti S, Mohd AB. Improved oral delivery of clonazepam through liquisolid powder compact formulations: in-vitro and ex-vivo characterization. Powder Technol 2014; 256: 336–344. |
APA Style
Andrew Chekwube Ezegbe, Grace Amarachi Ezegbe, Josephat Ikechukwu Ogbonna, Sabinus Ifeanyi Ofoefule. (2023). A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs. Science Frontiers, 4(2), 17-24. https://doi.org/10.11648/j.sf.20230402.11
ACS Style
Andrew Chekwube Ezegbe; Grace Amarachi Ezegbe; Josephat Ikechukwu Ogbonna; Sabinus Ifeanyi Ofoefule. A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs. Sci. Front. 2023, 4(2), 17-24. doi: 10.11648/j.sf.20230402.11
AMA Style
Andrew Chekwube Ezegbe, Grace Amarachi Ezegbe, Josephat Ikechukwu Ogbonna, Sabinus Ifeanyi Ofoefule. A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs. Sci Front. 2023;4(2):17-24. doi: 10.11648/j.sf.20230402.11
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Download@article{10.11648/j.sf.20230402.11,
author = {Andrew Chekwube Ezegbe and Grace Amarachi Ezegbe and Josephat Ikechukwu Ogbonna and Sabinus Ifeanyi Ofoefule},
title = {A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs},
journal = {Science Frontiers},
volume = {4},
number = {2},
pages = {17-24},
doi = {10.11648/j.sf.20230402.11},
url = {https://doi.org/10.11648/j.sf.20230402.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sf.20230402.11},
abstract = {Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Powdered solution technology involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. A liquid layer is formed on the particle surface which is instantly adsorbed by the coating material. This leads to the formation of a dry, free flowing and compressible powder. Coating material is required to cover the surface and maintain the powder flowability. A powder of known quantity can only retain limited amount of liquid medication while maintaining acceptable flowability and compressibility. A mathematical model has been introduced for liquisolid system that desires to have an acceptable flowable and compressible properties. Two fundamental properties characterize this model. They are the flowable liquid retention potential and the compressible liquid retention potential.},
year = {2023}
}
TY - JOUR T1 - A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs AU - Andrew Chekwube Ezegbe AU - Grace Amarachi Ezegbe AU - Josephat Ikechukwu Ogbonna AU - Sabinus Ifeanyi Ofoefule Y1 - 2023/07/06 PY - 2023 N1 - https://doi.org/10.11648/j.sf.20230402.11 DO - 10.11648/j.sf.20230402.11 T2 - Science Frontiers JF - Science Frontiers JO - Science Frontiers SP - 17 EP - 24 PB - Science Publishing Group SN - 2994-7030 UR - https://doi.org/10.11648/j.sf.20230402.11 AB - Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Powdered solution technology involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. A liquid layer is formed on the particle surface which is instantly adsorbed by the coating material. This leads to the formation of a dry, free flowing and compressible powder. Coating material is required to cover the surface and maintain the powder flowability. A powder of known quantity can only retain limited amount of liquid medication while maintaining acceptable flowability and compressibility. A mathematical model has been introduced for liquisolid system that desires to have an acceptable flowable and compressible properties. Two fundamental properties characterize this model. They are the flowable liquid retention potential and the compressible liquid retention potential. VL - 4 IS - 2 ER -
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