Volume 6, Issue 2, June 2018, Page: 7-18
Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis
Yue Wang, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Kunpeng Zhang, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Yali Hu, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Hongmei Ma, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Xiuyan Zheng, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Kelu Li, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Yanjuan Xie, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Lijuan Pang, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Lin Tao, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Jianming Hu, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Yan Qi, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Feng Li, Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Wenyi Gu, Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, Australia
Hong Zou, Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China
Received: Jun. 8, 2018;       Accepted: Jun. 26, 2018;       Published: Jul. 26, 2018
DOI: 10.11648/j.jctr.20180602.11      View  711      Downloads  48
Abstract
Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.
Keywords
China, Cervical Cancer, Human Papillomavirus, Meta-analysis
To cite this article
Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, Kelu Li, Yanjuan Xie, Lijuan Pang, Lin Tao, Jianming Hu, Yan Qi, Feng Li, Wenyi Gu, Hong Zou, Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis, Journal of Cancer Treatment and Research. Vol. 6, No. 2, 2018, pp. 7-18. doi: 10.11648/j.jctr.20180602.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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