Volume 7, Issue 2, June 2019, Page: 33-40
MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer
Carlos Ferrer Albiach, Radiation Oncology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain
Enrique Ochoa Aranda, Molecular Biology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain
Alfonso Gomez Iturriaga-Piña, Radiation Oncology, Cruces Baracaldo Hospital, Bilbao, Spain
Amalia Sotoca Ruiz, Radiation Oncology, International Hospital Ruber, Madrid, Spain
Fernando López Campos, Radiation Oncology, Hospital Ramony Cajal, Madrid, Spain
Mariano Porras Martinez, Radiation Oncology, Hospital Virgen de la Arrixaca, Murcia, Spain
Raquel García Gómez, Radiation Oncology, Hospital Virgen de la Arrixaca, Murcia, Spain
Manel Algara Lopez, Radiation Oncology, lmar Hospital, Barcelona, Spain
Virginia Ramos Fernandez, Pathology Department, Private Laboratory Dra Ramos, Valencia, Spain
Antonio Conde Moreno, Radiation Oncology Department, University Hospital la Fe, Valencia, Spain
Susana Ors, Molecular Biology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain
Esther Flores, Molecular Biology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain
Francisco Garcia Piñón, Investigation Unit, Provincial Hospital Consortium of Castellón, Castellón, Spain
Received: Jun. 17, 2019;       Accepted: Jul. 19, 2019;       Published: Aug. 6, 2019
DOI: 10.11648/j.jctr.20190702.12      View  25      Downloads  8
Abstract
The oligometastatic status in the prostate is a new entity of metastatic patients in which their treatment allows to improve survival over standard treatments. There are several theories about their biological origin, one of them being alterations in the expression of miRNas This. was a retrospective multicentre study undertaken in patients with oligometastatic prostate cancer who were diagnosed and treated at one of 7 different Spanish healthcare centres. METHODS: The study included 22 patients; healthy and primary tumour biopsy tissue was analysed in 7+2 of them in order to determine if they had a characteristic microRNA expression profile. We quantified the expression of the following miRNAs: mir‑200a, mir‑200b, mir‑200c, mir‑210, mir‑95, mir‑96, mir‑654‑3p, mir‑543‑3p, mir‑21, mir‑16‑5p, mir‑191‑5p, and mir‑93‑5p, with the latter three being endogenous‑expression controls. RESULTS: Our results show that miRNA95, and to a lesser extent, miRNA654‑3p, were significantly underexpressed (or their expression was suppressed) in tumour tissue samples compared to normal perilesional tissue in all our patients; miRNA95 was underexpressed in 67% of the patients in our sample However, we detected no relationship between miRNA95 expression and the Gleason scores obtained for our patients. CONCLUSIONS: The simple size in our series are limited, but they do allow us to infer that there could be a specific miRNA expression signature in oligometastatic patients with prostate cancer, which may be of great interest in the development of future clinical trials and subsequent studies.
Keywords
Microrna, Paraffin Blocks, Prostate Cancer, MetÁstasis Biology, Oligometastasis
To cite this article
Carlos Ferrer Albiach, Enrique Ochoa Aranda, Alfonso Gomez Iturriaga-Piña, Amalia Sotoca Ruiz, Fernando López Campos, Mariano Porras Martinez, Raquel García Gómez, Manel Algara Lopez, Virginia Ramos Fernandez, Antonio Conde Moreno, Susana Ors, Esther Flores, Francisco Garcia Piñón, MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer, Journal of Cancer Treatment and Research. Vol. 7, No. 2, 2019, pp. 33-40. doi: 10.11648/j.jctr.20190702.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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