Incidental Prostate Cancer: Predictors of Progression and Strategies of Management Based on Prostate-Specific Antigen
Masaru Morita,
Takeshi Matsuura
Issue:
Volume 2, Issue 6, November 2014
Pages:
56-60
Received:
17 November 2014
Accepted:
3 December 2014
Published:
15 December 2014
DOI:
10.11648/j.jctr.20140206.11
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Abstract: We studied predictors for the progression of incidental prostate cancer (PCa) to optimize the management strategies that are still controversial in the era of prostate-specific antigen (PSA). We performed advanced transurethral resection of the prostate (TURP) in 995 patients with benign prostate hyperplasia (BPH). Of these, 226 patients (22.7%) had incidental PCa. Included in the present study were 146 patients followed up for two years or longer. In the treated group of 26 patients whose PSA elevated, we performed radical transurethral resection of PCa (TURPCa) in 23 patients, palliative TURP in one, and endocrine therapy in two. Between the observed and treated groups, statistical differences were noted in PSA related parameters: preoperative PSA (Pre PSA), PSA three months after surgery (Post PSA), % Post PSA/Pre PSA (%PSA ratio), and PSA density (PSAD). No differences were noted in the clinical stage (T1a, T1b) and Gleason scores. Of 23 patients underwent radical TURPCa, one had pT0 disease, one showed PSA failure, and 19 had stable PSA. It may be rational and practical to decide the treatment strategy of incidental PCa based on PSA changes before and after TURP rather than Gleason scores or clinical stages.
Abstract: We studied predictors for the progression of incidental prostate cancer (PCa) to optimize the management strategies that are still controversial in the era of prostate-specific antigen (PSA). We performed advanced transurethral resection of the prostate (TURP) in 995 patients with benign prostate hyperplasia (BPH). Of these, 226 patients (22.7%) ha...
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Advanced Prostate Cancer Presenting as Epistaxis Only: A Case Report and Literature Review
Usman Mohammed Tela,
Audu Abdullahi Bukar,
Mala Bukar Sandabe,
Theophilus Maksha Dabkana,
Alhaji Bukar Musa,
Abubakar Sadiq Adamu
Issue:
Volume 2, Issue 6, November 2014
Pages:
61-63
Received:
13 December 2014
Accepted:
23 December 2014
Published:
4 January 2015
DOI:
10.11648/j.jctr.20140206.12
Downloads:
Views:
Abstract: Although Prostate cancer is the most frequently diagnosed cancer among men globally, its primary presentation as Epistaxis alone is quit uncommon. Epistaxis has numerous causes and hence poses early diagnostic challenge. We report a case of 68 year old man who presented with recurrent epistaxis as the main complaint .He was thoroughly evaluated and concluded to have a background asymptomatic advanced prostate cancer with isolated thrombocytopenia. He responded to blood transfusion and combined therapy form of Anti-androgen Deprivation Therapy. High index of suspicion is of paramount importance towards achieving early diagnosis of this unusual presentation.
Abstract: Although Prostate cancer is the most frequently diagnosed cancer among men globally, its primary presentation as Epistaxis alone is quit uncommon. Epistaxis has numerous causes and hence poses early diagnostic challenge. We report a case of 68 year old man who presented with recurrent epistaxis as the main complaint .He was thoroughly evaluated and...
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