Desmoid Tumour Treatment Outcome: A Single Institution Experience
Mohamed Wahba Hegazy,
Mohamed Rizwanullah
Issue:
Volume 10, Issue 4, December 2022
Pages:
38-42
Received:
3 November 2022
Accepted:
21 November 2022
Published:
27 December 2022
DOI:
10.11648/j.jctr.20221004.11
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Abstract: Desmoid tumors are benign tumor of connective tissue but with high chances of local recurrence. Surgery is the main treatment modality of therapy if it can be done with acceptable morbidity. Our purpose to present our experience in management of desmoid tumors and our aim is to evaluate the best option in dealing with desmoid tumors and factors affecting the Recurrence Free Survival. This is retrospective trial so medical records of patients diagnosed as desmoid tumors between January 2009 and December 2018 were reviewed at Radiation Oncology section, King Faisal Specialist Hospital & Research Centre (KFSH&RC), Riyadh, Saudi Arabia. Our cohort was 72 consecutive patients. The median age was 27 years, two-thirds were females, median size was 7 cm and most common site was trunk. Twenty four patients were treated with definitive radiotherapy, 15 patients by surgical resection alone and 30 patients by combination of both surgery and radiotherapy. The median follow up was 5.5 years with local control in patients who had radiotherapy as part of treatment was 89% and 87% in patients who had surgery as a part of treatment. The patients who had surgery alone had no recurrence. All the recurrences happened in the lower radiotherapy dose of 50Gy and those who had postoperative radiotherapy. There was no recurrence in the higher radiotherapy dose of 60Gy and those who had preoperative radiotherapy. Most of the recurrence was in patients with tumor size less than 5 cm, in the extremities and in the less than 30 years old group. The 3 years, 5 years and 7years Recurrence Free Survival in patients who had both surgery and radiotherapy was 96.4%, 81.4% and 77.4% respectively. Radiotherapy plays an important role in local control of desmoid tumors. The factors associated with poor response in the cohort of patients are younger age group, lower dose of radiation and post-operative radiotherapy compared to preoperative radiotherapy. The majority of the recurrent tumors were small indicating that biology of the disease is more important.
Abstract: Desmoid tumors are benign tumor of connective tissue but with high chances of local recurrence. Surgery is the main treatment modality of therapy if it can be done with acceptable morbidity. Our purpose to present our experience in management of desmoid tumors and our aim is to evaluate the best option in dealing with desmoid tumors and factors aff...
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