Early Predictors of the Endometrium Cancer Recurrence in Our Environment
Lopez Gonzalez Elga,
Montero Venegas Francisco Manuel,
Camacho Carrasco Maria
Issue:
Volume 9, Issue 2, June 2021
Pages:
22-26
Received:
26 May 2021
Accepted:
8 June 2021
Published:
16 June 2021
Abstract: Objective: to find out the predictors in the recurrence of the illness in patients suffering from endometrium cancer at the differet stages of it. Material and Method: Retrospective study of 170 patients who were diagnosed with endometrium cancer between 2013-2017 at “Juan Ramon Jimenez” Hospital in Huelva. Variables such us age, degree of tumour differentation, miometrial invasion (MI), post surgical staging and lympho-vascular space infiltration (LVSI) were analysed in all those patients that had recurrences during the period of the study. The study was sone by using SPSS 23rd V. Once the analysis of Kolmorov-Smirnov concluded in an unusual result; the Chi-Squared test was used in order to obtain parametric categorical data; whereas the U (by Mann Whitney) test was used for the non-parametric data. P<0.01 was accepted as significant from a statistic point of view. results: During the study, 9 patients were diagnosed with tumoral affects recurrence. This means 5.3 % out of the whole sample. The statistic analysis concluded that there is no relation of dependence among the recurrence varible and the Miometrial Invasion variable (χ2=4.780,p=0.092) recurrence and Tumor grade (χ2=7.765, p=0.051) and recurrence and post surgical (χ2=10.200, p=0.070). On the contrary, it is stated that there is a relation of dependence among lymph-node damage variable and LSVI+(χ2=9.954, Cc=0.235, p<.01). The existence of LSVI was evaluated in all the patients. lVSI was negative in 141 cases and 4 of these cases had recurrence of the illness 55.5 % of the patients in which the illness recurred had positive LVSI (5 out of 9). Conclusions: our results proved that more than a half of the patients with recurrence of the illness have Lympho-vascular infiltration and also; if the LVSI is negative, there is a risk of 2.8% of having recurrence. Although it would be neccessary to carry out prospective multi-center studies, this preliminary study determines an obvious relation between LVSI and the recurrence in a short or long term period. Again, The variable that stablishes the LVSI can be a relevant datum when dealing with the staging process of the endometrium cancer, apart from being very useful in the prediction of the illness recurrence.
Abstract: Objective: to find out the predictors in the recurrence of the illness in patients suffering from endometrium cancer at the differet stages of it. Material and Method: Retrospective study of 170 patients who were diagnosed with endometrium cancer between 2013-2017 at “Juan Ramon Jimenez” Hospital in Huelva. Variables such us age, degree of tumour d...
Show More
Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review
Katherine Jinghua Lin,
Cecile Lengacher,
Carmen Rodriguez,
Laura Szalacha,
Jennifer Wolgemuth
Issue:
Volume 9, Issue 2, June 2021
Pages:
27-44
Received:
25 May 2021
Accepted:
11 June 2021
Published:
21 June 2021
Abstract: Objectives: The major aims of this integrative review were to identify: 1) specific cognitive domains affected by chemotherapy; 2) predictors of cognitive dysfunction related to chemotherapy; 3) reported underlying mechanisms of chemotherapy-related cognitive dysfunction, and 4) clinical and research implications of chemotherapy-related cognitive dysfunction (CRCD) among breast cancer survivors. Methods: A computerized search of published research articles through the health journal databases of PubMed, CINAHL, EMBASE, and Web of Science was performed by using the keywords "chemotherapy," "cognitive dysfunction," "cognitive impairment," "cognitive decline," "breast cancer," and "breast carcinoma." References were screened according to inclusion and exclusion criteria. Results: After screening the titles and abstracts of 639 articles, 20 research studies were identified that focused on chemotherapy-related cognitive dysfunction in breast cancer for the final analysis. The 20 studies included: one longitudinal study, eleven prospective studies, two case-control studies, two retrospective studies, and four cross-sectional studies. The analysis of these 20 research studies contributed new knowledge about cognitive domains being affected by chemotherapy, risk factors for CRCD and underlying mechanisms of CRCD. Conclusion: This systematic review indicates significant clinical implications of early assessment and early interventions for CRCD to assist breast cancer survivors.
Abstract: Objectives: The major aims of this integrative review were to identify: 1) specific cognitive domains affected by chemotherapy; 2) predictors of cognitive dysfunction related to chemotherapy; 3) reported underlying mechanisms of chemotherapy-related cognitive dysfunction, and 4) clinical and research implications of chemotherapy-related cognitive d...
Show More
